Lille
28.09.2025 18:15 (GMT+2)
Lyon
[1] - 2.26
Х - 3.66
[2] - 3.08
1$
2.26
1$
3.08

Lille — Lyon : Match Preview and Prediction for September 28,2025

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Lille team logo

Lille

Flag of France
Bruno Genesio
Coach since July 1, 2024

Lille’s Challenging Form

Lille approaches this match in a state of disarray. The team is suffering from a true epidemic of injuries that has sidelined key players. The infirmary is overflowing, and coach Bruno Genesio faces a personnel catastrophe – a staggering eight players are out of contention.

Goalkeeping Crisis

The primary issue lies in the goalkeeping department. First-choice goalkeeper Berke Özer sustained a muscle injury and will not play. His place will be taken by Belgian Arnaud Bodart, who was previously the second-choice and has no experience. This presents an enormous risk in a match against one of the league’s top attacking sides.

Defensive Woes and Key Absentees

But the troubles don’t end there. Captain and midfield lynchpin Benjamin André is also not 100% fit, and his participation in the match is a significant health risk. In addition, defenders Thomas Meunier and Alexsandro are out. Effectively, Genesio will have to construct his defense from what remains, which severely impacts cohesion and reliability.

Recent Results and Morale

Compounding these issues is a less-than-ideal psychological state. In the previous league round, “Les Dogues” were decisively beaten 0-3 in the derby against Lens. Moreover, their Europa League victory against modest Norwegian side Brann (2-1) was hard-fought and only secured in the 80th minute thanks to a goal from veteran Olivier Giroud. This result cannot be described as convincing, as the team has conceded goals in four consecutive matches, indicating clear defensive problems.

League Standings

#
Team
P
W
D
L
GF-GA
Pts
4
Lyon
5
4
0
1
7-3
12
5
Strasbourg
6
4
0
2
9-7
12
6
Lille
5
3
1
1
13-8
10
7
Lens
5
3
0
2
8-5
9
8
Rennes
5
2
2
1
7-8
8
Champions League (Qualification)
Promotion – Europa League (Group Stage)
Promotion – Conference League (Qualification)
Show Full Table

Injuries and Suspensions

  • Injury Thomas Meunier Starting Defender Starting Player
    2 matches played
    0 goals scored
    September 7 out since
    3 matches missed
  • Injury Alexsandro Starting Defender Starting Player
    4 matches played
    0 goals scored
    September 14 out since
    2 matches missed
  • Injury Ousmane Toure Rotational Defender Rotational Player
    1 match played
    0 goals scored
    August 17 out since
    5 matches missed

Players Questionable

  • Injury Romain Perraud Starting Defender Starting Player
    5 matches played
    1 goal scored
    September 20 out since
    1 match missed

Players Returned to Squad

  • Injury Benjamin André Key Midfielder Key Player
    4 matches played
    0 goals scored
    September 14 out since
    2 matches missed
  • Injury André Gomes Rotational Midfielder Rotational Player
    0 matches played
    0 goals scored
    September 20 out since
    1 match missed
  • Injury Hugo Raguber Reserve Midfielder Reserve Player
    1 match played
    0 goals scored
    August 30 out since
    3 matches missed
  • Injury Ethan Mbappé Reserve Midfielder Reserve Player
    2 matches played
    1 goal scored
    September 20 out since
    1 match missed
  • Injury Marc-Aurèle Caillard Reserve Goalkeeper Reserve Player
    0 matches played
    0 goals scored
    May 17 out since
    11 matches missed

Lyon team logo

Lyon

Flag of Portugal
Paulo Fonseca
Coach since Jan 31, 2025

Lyon’s Impressive Start

Lyon, however, is currently in full stride. Paulo Fonseca’s team has showcased powerful football since the start of the season, securing 4 victories in 5 rounds. Their only defeat occurred in a match against Rennes, where “Les Gones” were reduced to ten men while leading.

Impenetrable Defense

Lyon’s main asset is its rock-solid defense. They have conceded only 3 goals in 5 rounds, keeping clean sheets in 4 out of 5 matches. New goalkeeper Dominik Greif has seamlessly integrated into the squad and has already achieved two clean sheets in his first two games. The central defensive partnership of Moussa Niakate and Clinton Mata appears very solid.

Squad Health and Morale

Unlike Lille, Lyon has virtually no personnel losses. Fonseca confirmed in a press conference that almost all players are ready for the game. The positive atmosphere within the team is further reinforced by a recent away victory in the Europa League against Utrecht (1-0).

Potent Attack

The attack is also in excellent order. The team has scored in six consecutive matches, and midfielder Tanner Tessmann is in superb form, having netted two goals in his last two appearances. This indicates that the threat to the opponent’s goal comes not only from the forwards but also from deeper midfield positions.

League Standings

#
Team
P
W
D
L
GF-GA
Pts
2
PSG
5
4
0
1
10-4
12
3
Monaco
6
4
0
1
14-10
12
4
Lyon
5
4
0
1
7-3
12
5
Strasbourg
6
4
0
2
9-7
12
6
Lille
5
3
1
1
13-8
10
Promotion – Champions League (Group Stage)
Champions League (Qualification)
Promotion – Europa League (Group Stage)
Promotion – Conference League (Qualification)
Show Full Table

Injuries and Suspensions

  • Injury Rémy Descamps Rotational Goalkeeper Rotational Player
    4 matches played
    0 goals scored
    September 14 out since
    2 matches missed
  • Injury Abner Vinícius Rotational Defender Rotational Player
    4 matches played
    0 goals scored
    September 14 out since
    2 matches missed
  • Injury Ernest Nuamah Reserve Forward Reserve Player
    0 matches played
    0 goals scored
    August 2 out since
    7 matches missed

Players Returned to Squad

  • Suspension Corentin Tolisso Starting Midfielder Starting Player
    5 matches played
    2 goals scored
    September 19 out since
    1 match missed

Final Verdict and Betting Tip

Here, I fail to see how Lille can secure a victory. The odds of 1.68 for Lyon not to lose (X2) appear highly attractive, and I will explain why. On one side, we have Lille with immense squad problems: without their main goalkeeper, without their captain, and with a reshuffled defensive line. 

History of confrontations

Last matches Lille vs Lyon

Lille Lille
Lyon

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Mark Thompson
Mark Thompson, a London-based journalist with 15 years of experience, is renowned for his deep knowledge of sports betting. His passion for football and analytical mind enable him to create accurate match predictions. Thompson regularly publishes articles revealing the intricacies of bookmaking. His ability to interpret statistics and assess team form is highly valued by readers and fellow professionals alike.
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